Clinical Trials and Studies
Some clinical trials have suspended enrollment until further notice due to COVID-19 considerations.
Allergy and Asthma
Alzheimer’s Disease and Related Dementias
- AHEAD 3-45
- Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)
- Alzheimer's Genetics Family Study
- Effect of Weight Loss Diets on Brain Health and Cognitive Decline Study
- Metformin in Alzheimer's Dementia Prevention (MAP)
- PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)
- Rush Memory Clinic Data Repository
- Study of ATH-1017 for the Treatment of Alzheimer's Disease
- Study of the Impact of Lifestyle Modifications on Thinking and Brain Health
- The Chronic Grief Management Intervention Study
- TRC-PAD Study
Arthritis and Other Rheumatic Diseases
Autism Spectrum Disorders
- Argus MDS: Developing Digital Tools for Diagnosis & Treatment Monitoring
- Mapping the Genotype, Phenotype, and Natural History of Phelan-McDermid Syndrome (PMS)
- RISE: Training and Implementation of Evidence-Based Intervention in the Part C Early Intervention System
- SPARK: Simons Foundation Powering Autism Research for Knowledge
Blood Disorders and Hematologic Cancers
- A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)
- AB-101 with or without Rituximab for Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
- Assessing the Anti-Tumor Activity and Safety of REGN1979 in Patients with Relapsed or Refractory Follicular Lymphoma
- Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease Treatment Study
- Cold Agglutinin Disease Real World Evidence Registry
- Drug Treatment Study for Children with Hemophilia A
- Evaluation of Pediatric Palliative Inpatient Process
- Expanded Access Protocol (EAP) for Subjects Receiving Lisocabtagene Maraleucel
- Health Literacy and Numeracy in Adolescent Patients with Hemophilia A and B Study
- Hemophilia A or B Treatment Study
- Hemophilia A Treatment Study
- Luspatercept versus Placebo in Subjects with Myeloproliferative Neoplasm-Associated Myelofibrosis
- Molecular and Clinical Biology of von Willebrand Disease Study
- National Registry of All Persons with Bleeding and Clotting Disorders
- Newly Diagnosed T-Lymphoblastic Leukemia and T-Lymphoblastic Lymphoma Treatment Study
- Public Health Surveillance for the Prevention of Complications of Bleeding and Clotting Disorders
- Study for Patients with Acute Myelogenous Leukemia
- Study for Patients with Myelofibrosis and Indolent Systemic Mastocytosis
- Study of Biomarkers in Hemophilic Arthropathy
- Study of Hepatitis C Virus Outcomes After Treatment in Patients with Bleeding Disorders
- Study Treating Patients With High-Risk Smoldering Myeloma
- Treatment Option for Relapsed or Refractory Multiple Myeloma
- Treatment Study for Children with Hemophilia B
- Treatment Study for Newly Diagnosed High Risk B-Lymphoblastic Leukemia in Patients with Ph-like TKI Sensitive Mutations
- Treatment Study for Patients with Localized Central Nervous System Germ Cell Tumors
- Treatment Study for Patients with Newly Diagnosed B-Lymphoblastic Leukemia or B-Lineage Lymphoblastic Lymphoma
- Treatment Study for Pediatric Patients with Hemophilia A
- Treatment Study for Subjects with Severe Hemophilia A or B
- Treatment Study for Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
Brain Tumors
- Meningioma Drug Treatment Study
- Observation or Radiation Therapy in Treating Patients with Newly Diagnosed Grade II Meningioma that has been Completely Removed by Surgery
- Post-Surgical SRT Versus STaRT with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors
- Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
Breast Cancer
- A Phase I Study to Evaluate the Safety of Intratumoral Influenza Vaccine Administration in Patients with Breast Cancer
- De-Escalation of Breast Radiation Trial (DEBRA)
- Estrogen Receptor Status Study
- Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25 (OFSET)
- NSABP B-63/ASCENT-05/GS-US-595-6184
- Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
- Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer (SCARLET)
- Study for Patients with Metastatic Solid Tumors and Metastatic Breast Cancer
- Study of Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer (TAILOR RT)
- The CompassHER2 RD Trial for High Risk HER2-Positive Breast Cancer
COVID-19
- A Study for Outpatients with COVID-19
- COVID-19 Outpatient Thrombosis Prevention Trial
- COVID-19 Treatment Study for Non-Hospitalized Participants
- COVID-19 Vaccine Questionnaire
- Moderate Versus High Dose Vitamin D for Prevention of COVID-19
- RECOVER AUTO
- Shift Worker’s Resiliency to COVID-19
- Study of High-Flow Nasal Cannula with Prone Position for COVID-19 Acute Respiratory Distress Syndrome
Dermatology
Diet and Nutrition
- Effect of Weight Loss Diets on Brain Health and Cognitive Decline Study
- Enhanced Lifestyles for Metabolic Syndrome: A Multi-Site Trial
- NOURISH Study
- Response to Behavioral Obesity Treatment (REBOOT) Study for Weight Loss
- Study of Eating Patterns and Alcohol Consumption in Patients with Advanced Tubular Adenoma
Digestive Disorders
- Act Fast Study for Patients with Colorectal Cancer or Colorectal Lesion
- Chronotherapy in Ulcerative Colitis
- Colonoscopy Research Study
- Efavaleukin Alfa Treatment for People with Ulcerative Colitis
- Gastrojejunostomy in Gastric Outlet Obstruction
- Growth of Colon Tissue to Evaluate GI
- Inflammatory Bowel Disease (IBD) Registry
- New Treatment Development for People with Crohn's Disease
- Pancreatic Cancer Screening Study
- Paradoxical Diarrhea Treatment Study
- PATENT-E Study for Chronic Benign Stricture
- Study of Eating Patterns and Alcohol Consumption in Patients with Advanced Tubular Adenoma
- The COSMID Study for Patients with Diverticulitis
- The Impact of Sleep on Ulcerative Colitis
Ear, Nose and Throat
- Safety and Efficacy of CYR-064 Theophylline Nasal Spray for the Treatment of Post-Viral Hyposmia
- Sleep and Think: Help Us Understand How CRS Affects How We Think
- Study to Evaluate LYR-210 for the Treatment of Chronic Rhinosinusitis (CRS)
- The Vivaer Procedure for Treatment of the Septal Swell Bodies (SWELL)
Emergency Medicine
Fragile X Syndrome
Gastrointestinal Cancers
- Act Fast Study for Patients with Colorectal Cancer or Colorectal Lesion
- Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
- Colonoscopy Research Study
- Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study
- Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer
- Growth of Colon Tissue to Evaluate GI
- Initial Feasibility Study to Treat Pancreatic Cancer With a Planar LDR Source
- Pancreatic Cancer Screening Study
- Refractory Small Bowel Adenocarcinoma Treatment Study
- Retrospective Chart Review of Patients with Fibrolamellar Carcinoma
- Study for Patients with Hepatocellular Carcinoma (HCC)
- Study of Eating Patterns and Alcohol Consumption in Patients with Advanced Tubular Adenoma
- The COMMIT Study: Combination Chemotherapy, Bevacizumab, and/or Atezolizumab in Treating Patients With Deficient DNA Mismatch Repair Metastatic Colorectal Cancer
- The DECREASE Study: Treatment of Early-Stage Anal Cancer
Genitourinary Cancers
- Chemoradiotherapy Study for Patients with Localized Muscle Invasive Bladder Cancer
- Prostate Cancer Study
- Prostate Cancer: De-Intensification and Intensification Clinical Trial
- Study of Standard Systemic Therapy in Treating Prostate Cancer
- Study to Test Radium-223 with Docetaxel in Patients with Prostate Cancer
- The ICONIC Trial for Rare Genitourinary Cancers
- The PREDICT-RT Trial for Patients with High Risk Prostate Cancer
- The PROBE Trial: Treatment Study for Metastatic Kidney Cancer
- The RadiCaL Study: Testing the Addition of a New Anti-Cancer Drug to the Usual Treatment for Advanced Renal Cell Cancer that has Spread to the Bone
- Treating Participants With Metastatic Prostate Cancer
- Treating Patients With High Risk Prostate Cancer
- Treatment Study for Patients With Muscle-Invasive Bladder Cancer
- Treatment Study for Rare Genitourinary Cancers
Gut and Oral Microbiome
Gynecologic Cancers
Head and Neck Cancer
- Advanced Pneumatic Compression Device
- Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
- EP0031-101: A Study of EP0031 in Patients with Advanced RET-Altered Malignancies
- HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer Treatment Study
- Testing Immunotherapy Versus Observation in Patients with HPV Throat Cancer
- Treatment Study for Squamous Cell Carcinoma of the Head and Neck
Heart and Vascular Conditions
- AAD Cross Over Study
- AIM-VT Trial
- ALLIANCE: Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve
- APOLLO Trial: Treatment of Mitral Regurgitation
- Apple Watch Versus Zio Patch
- BOLT: DVT Indigo Aspiration System
- Clinical Investigation Comparing Patent Foramen Ovale (PFO) of Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion
- Deep Vein Arterialization for Amputation Prevention in PAD Patients
- Deeper Reveal
- Disrupt PAD BTK II Study
- ELEGANCE: Real-World Treatment of Lesions in the Peripheral Vasculature
- HIS-CRT
- Intravascular Ultrasound-Guided Treatment of Complex Lesions (IMPROVE)
- Left Vs Left
- MOTIVE BTK RCT: Study for the Treatment of Infrapopliteal Lesions
- Rhythm Evaluation for AntiCoagulaTion with Continuous Monitoring of Atrial Fibrillation (REACT-AF)
- Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (REDUCE PAS)
- STORM-PE
- Study of the Heartlight Endoscopic Ablation System for the Treatment of Atrial Fibrillation
- The C-TRACT Trial
- The FLUOROLESS HBP Trial
- The PROMISE III Trial
- THERMOCOOL SMARTTOUCH for Treatment of Drug Refractory Symptomatic Paroxysmal Atrial Fibrillation
Kidney and Urinary System Disorders
Liver, Biliary and Pancreatic Disorders
Lung and Chest Tumors
- ALCHEMIST Chemo-IO Study: Treatment for Treatment for Non-Small Cell Lung Cancer
- An ALCHEMIST Treatment Trial: Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer
- Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
- Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
- Pulmonary and Critical Care Registry
- Study of First Line Treatment and Maintenance in Non-Small Cell Lung Cancer
- TETON Study: Inhalation Treatment for IPF
- The ALCHEMIST Screening Trial: Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer
Melanoma and Soft Tissue
Mental Health Disorders
- Brain Training: Computer Games for Improved Cognition
- Clinical Research Study for Adolescents with Schizophrenia
- COMP360 Psilocybin for Treatment-Resistant Depression
- Depression Treatment Study
- ON-DEQ Study: A Nationwide, Remote Study to Help Smokers Increase Their Readiness to Quit
- Racial Microaggressions Toward People of Color During Physical Therapy
- The Impact of Weekly Friendly Calls on Social Engagement and Health
- The RECOVER Study: Vagus Nerve Stimulation for People with Difficult-to-Treat Bipolar Depression
Multiple Sclerosis
Neurological Disorders
- Cellular Autoimmune Mechanisms of Narcolepsy Study
- Ecopipam in Children, Adolescents and Adults with Tourette’s Disorder (EBS-101-TD-301)
- Human Cortical Visual Prosthesis in People with Blindness
- Meningioma Drug Treatment Study
- Observation or Radiation Therapy in Treating Patients with Newly Diagnosed Grade II Meningioma that has been Completely Removed by Surgery
- SAGE-324 for the Treatment of Essential Tremor (Protocol No. 324-ETD-202)
- Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease
- Study of Inflammation in Progressive Multifocal Leukoencephalopathy
- Study of Viruses in Patients with Neurological Disorders and Infections
- The Rush Cancer Biorepository Resource
- Treatment Study for Adults with Early Manifest Huntington Disease
Orthopedic Conditions
Pain Management
Parkinson's Disease and Other Movement Disorders
- Chorea Associated with Huntington’s Disease Treatment Study
- Fracture Prevention Study
- Gut-Brain Health
- Huntington's Disease Cohort Prospective Registry Study
- Levodopa-Induced Dyskinesia in Parkinson's Disease
- LRRK2 in Early Parkinson's Disease
- Multiple System Atrophy (MSA) with Orthostatic Hypotension (CYPRESS 0197)
- NIH Racial Disparities in Parkinson's Disease
- Non-Pharmacological Study of Exercise in Parkinson's Disease
- ONO-2808 for Early Stage Multiple System Atrophy (MSA)
- Parkinson's Disease Genetics in the African American Population
- Peer Mentor Support and Caregiver Education
- Study of Constipation in Patients with Parkinson’s Disease
- Treatment Study for Adults with Early Manifest Huntington Disease
Pediatric Cancers and Blood Disorders
- Childhood B-Lymphoblastic Leukemia Treatment Study
- Hepatoblastoma Treatment Study
- Newly Diagnosed Classical Hodgkin Lymphoma Treatment Study
- Retrospective Chart Review of Patients with Fibrolamellar Carcinoma
- Study of Transient Myeloproliferative Disorder in Children with Down Syndrome
- Treatment Study for Patients with Acute Myeloid Leukemia
- Treatment Study for Patients with Anaplastic Large Cell Lymphoma
- Treatment Study of Non-Metastatic Desmoplastic Medulloblastoma in Children
Pediatric Neurological Disorders
- Drug Treatment Study for Boys with Duchenne Muscular Dystrophy
- Duchenne Muscular Dystrophy Treatment Study
- Efficacy, Safety and Tolerability of RO5186582 in Adults and Adolescents with Down Syndrome
- Expressive Language Sampling as an Outcome Measure
- Extension Study of Ataluren Treatment for Nonsense Mutation Dystrophinopathy
- Fragile X Study: Premutation Carriers
- Nonsense Mutation Dystrophinopathy and Ataluren Treatment Study
- Treatment Study for Boys with Duchenne Syndrome
Plastic and Reconstructive Surgery
Sleep
Spine and Back Disorders
- Chronic Low Back Pain Treatment Study
- Degenerative Disc Disease Treatment Study
- Effects of Aerobic Exercise on Chronic Lower Back Pain Study
- FUSE Study
- Lumbar Degenerative Spondylolisthesis Treatment Study
- Lumbar Spinal Fusion Treatment Study
- Mindfulness and Spinal Manipulation Therapy for Chronic Low Back Pain
- Registry for Prospective Radiographic and Clinical Evaluation of Surgical Treatment for Cervical Deformity
- Registry for the Management and Outcome of Metastatic Spine Tumors
- Spinal Deformity Outcomes Database Registry
- Stryker Adherus
Stroke and Cerebrovascular Disease
- Acute Ischemic Stroke Treatment Study
- ARAMIS Registry: Addressing Anticoagulant Management Issues in Stroke
- ENRICH Trial: Comparison Study in the Treatment of Intracerebral Hemorrhage
- MyRIAD Study
- Prevention of Stroke Recurrence in Patients with Embolic Stroke Study
- PRISMS Study
- PROST: pRESET for Occlusive Stroke Treatment
- Select 2: Trial to Optimize Patient’s Selection for Endovascular Treatment in Acute Ischemic Stroke
- Spontaneous Intracerebral Hemorrhage and Diffusion Weighted Imaging
- Study of Intravenous Thrombolysis Related Coagulopathy in Acute Ischemic Stroke
- SURF: Research Registry for Patients with the SMART COIL System
- Transient Ischemic Attack Study (POINT)
- Treatment Study of Intracranial Dural Arteriovenous Fistulas