Study of the Impact of Lifestyle Modifications on Thinking and Brain Health

The purpose of this study is to assess how lifestyle modifications such as physical activity, diet, cognitive exercises and social support can protect brain health in older adults who are at a higher risk for memory issues. This study is a multicenter, randomized 2-year clinical trial of two lifestyle interventions varying in intensity and format, in 2000 older adults at increased risk of cognitive decline and dementia in the United States. Those eligible to participate must: be between the ages of 60-79, not regularly exercise, have normal cognition (no memory impairment) and meet additional criteria evaluated throughout the screening process.

Those who advance throughout the screening process and are deemed eligible to participate in the US POINTER study will be randomly assigned to one of two groups: Structured or Self-guided. The self-guided group will design and practice a lifestyle program that best fits their own needs and schedules, while the other group follows a more regimented program that includes weekly activities designed to promote health. Both groups receive regular monitoring of blood pressure, cognition, and other health assessments throughout the duration of the study.

In order to participate you must meet the following criteria:

• Are between the ages of 60-79 year old.
• Have normal cognition (no memory problems).
• Do not regularly exercise.

You will be excluded from the study if any of the following criteria apply to you:

• Are outside the ages of 60-79 years old.
• Have existing memory impairment.
• Exercise vigorously.

This is a partial list of inclusion and exclusion criteria.