The Role of Cerebral Hemodynamics in Moyamoya Disease

Moyamoya disease is a destructive disease of the blood vessels, specifically of the large arteries at the base of the brain.

In the United States, it most commonly affects women in their third and fourth decades of life, frequently causing ischemic stroke.

This study involves measurement of brain blood flow and oxygen use with a PET scanner, and clinical follow up over years.

High-resolution MR-imaging study to image the wall of the narrowed artery. This is a pilot study supported by Mallinckrodt Institute of Radiology.

You may be eligible to participate in this study if you:

• Are an adult > 18 years of age
• Are capable of informed consent

You will be excluded from this study if you:

• Have any other disease that might be responsible for the vasculopathy, including atherosclerosis, neurofibromatosis, meningitis, sickle cell disease and skull base radiation therapy
• Are pregnant: All women of child-bearing potential will be tested for pregnancy using a urine b-HCG test on the day of the enrollment and follow up PET scans

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via e-mail, please include the title of the study in your message.