A Study of the efficacy of augmenting selective serotonin reuptake inhibitor (SSRI) medication in patients with major depressive disorder (MDD) resistant to treatment with SSRIs.

Participants on a stable, acceptable dose of an acceptable antidepressant medicine will receive study drug or placebo augmentation (this is an add-on to the antidepressant medicine) for 60 days, during which time they will be seen every 10 days for evaluation.

At the study’s conclusion, participants may continue the study drug on an open label, or non-blinded, basis at no charge for 12 months, during which time they will be seen quarterly for evaluation.

You may be eligible to participate in this study if you:

• Are diagnosed as clinically depressed
• Have been medicated with an acceptable antidepressant for at least 8 weeks
• Are 18-65 years of age
• Have no history of seizures

This is a partial list of eligibility requirements. To inquire about your eligibility, please call the contact number provided. If you wish to inquire via e-mail, please include the title of the study in your message.